AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.
نویسندگان
چکیده
Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 microg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 microg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.
منابع مشابه
Roles of Salmonella multidrug efflux pumps in tigecycline resistance.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 2 شماره
صفحات -
تاریخ انتشار 2005